Characterization of early hypoxic-ischemic injuries to the neonatal mouse cerebral cortex and hippocampus using diffusion tensor imaging
نویسندگان
چکیده
J. Nogee, B. S. Stone, D. W. Mack, L. J. Martin, M. I. Miller, S. Mori, F. J. Northington, and J. Zhang Johns Hopkins University School of Medicine, Baltimore, MD, United States, Pediatrics, Johns Hopkins University School of Medicine, Pathology, Johns Hopkins University School of Medicine, Center of Imaging Science, Johns Hopkins University, Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
منابع مشابه
Neonatal hypoxic-ischemic encephalopathy: detection with diffusion-weighted MR imaging.
BACKGROUND AND PURPOSE Although diffusion-weighted imaging has been shown to be highly sensitive in detecting acute cerebral infarction in adults, its use in detecting neonatal hypoxic-ischemic encephalopathy (HIE) has not been fully assessed. We examined the ability of this technique to detect cerebral changes of acute neonatal HIE in different brain locations. METHODS Fifteen MR examination...
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Neonatal hypoxic-ischemic encephalopathy is a major cause of brain damage in infants, and is associated with periventricular white matter injury and chronic neurological dysfunctions. However, the mechanisms of the chronic white matter injury and reorganization are still unclear. In this study, in vivo diffusion tensor imaging (DTI) was employed to evaluate the late changes of white matter micr...
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With improvements in care of at-risk neonates, more and more children survive. This makes it increasingly important to assess, soon after birth, the prognosis of children with hypoxic-ischemic encephalopathy. Computed tomography, ultrasound, and conventional magnetic resonance imaging are helpful to diagnose brain injury, but cannot quantify white matter damage. In this study, ten full-term inf...
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BACKGROUND This investigation aimed to evaluate changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of white matter injury (WMI) in preterm neonates with hypoxic-ischemic encephalopathy (HIE) using diffusion tension imaging (DTI). MATERIAL AND METHODS Thirty-eight neonates less than 37 weeks of gestation with leukoencephalopathy (as observation group) and 38 full-term...
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